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вce журналы << Медицинская визуализация << 2015 год << №1 <<
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Сравнительная характеристика радиофармацевтических препаратов для визуализации воспалительных и инфекционных процессов методом эмиссионной томографии

Лунёв А. С., Лысенко Н. П., Петросова К. А.
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Лунёв Александр Сергеевич - аспирант кафедры радиобиологии и вирусологии, ФГБОУ ВПО” Московская государственная академия ветеринарной медицины и биотехнологии им. К.И. Скрябина”, l5h33@rambler.ru, Москва, Россия
Лысенко Николай Петрович - доктор биол. наук, заведующий кафедрой радиобиологии и вирусологии, ФГБОУ ВПО” Московская государственная академия ветеринарной медицины и биотехнологии им. К.И. Скрябина”, Москва, Россия
Петросова Кристина Андреевна - инженер отдела радиационных технологий в ядерной медицине, ФГБУ ГНЦ “Федеральный медицинский биофизический центр им. А.И. Бурназяна” ФМБА России, Москва, Россия

Визуализация и радионуклидная диагностика воспалительных и инфекционных процессов методами эмиссионной томографии, основывающейся на локальных физико-химических изменениях в пораженной ткани, позволяет отразить функциональный статус патологии, тогда как другие современные методы визуализации (КТ, МРТ, УЗИ) опираются на морфологические изменения в тканях, что лишает возможности оценить патологию на ранней стадии развития. К сожалению, на сегодняшний день нет “идеального” радиофармпрепарата, отвечающего определенным критериям, поэтому многолетний мировой опыт использования меченых агентов для визуализации воспалений и их конкретные позитивные результаты явились основанием в предоставлении достаточного количества препаратов для независимого выбора применения того или иного агента.

Ключевые слова:
радиофармпрепарат, визуализация, воспаление, инфекция, radiopharmaceutical, imaging, inflammation, infection

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Comparative Analysis of Radiopharmaceuticals for Imaging of Inflammation and Infection using Emission Tomography

Lunyov A. S., Lysenko N. P., Petrosova K. A.

Emission imaging and radionuclide diagnostics of inflammation and infection are based on local physical and chemical changes of affected tissue. Emission imaging allows demonstrating functional status of pathology while other modern methods (CT, USG and MRI) are based on morphological changes. Imaging using radiopharmaceutical allows estimating foci of early development stage. Unfortunately, nowadays there is no “ideal” radiopharmaceutical (fast accumulation in inflammation, fast excretion, low toxicity, discrimination between inflammation and infection, low cost). Therefore, the world experience of radiopharmaceutical using for inflammation imaging and their positive results were providing foundation of sufficient number of radiopharmaceuticals for independent select of using different labeled agents.

Keywords:
радиофармпрепарат, визуализация, воспаление, инфекция, radiopharmaceutical, imaging, inflammation, infection

ООО Издательский дом ВИДАР-М, 2016