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Медицинская литература. Новинки


 

 

 

 

 

 
вce журналы << Медицинская визуализация << 2015 год << №6 <<
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Диффузионно-взвешенные изображения при очаговой патологии печени: обзор литературы

Ломовцева К. Х., Кармазановский Г. Г.
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Ломовцева Карина Хусаиновна - аспирант кафедры лучевой диагностики Института профессионального образования ГБОУ ВПО “Первый МГМУ им. И.М. Сеченова” МЗ РФ, ГБОУ ВПО “Первый Московский государственный медицинский университет им. И.М. Сеченова” Минздрава России, lomovtsevakarina@gmail.com, 119991 Москва, Трубецкая ул., 8, стр. 2
Кармазановский Григорий Григорьевич - доктор мед. наук, профессор, профессор кафедры лучевой диагностики Института профессионального образования ГБОУ ВПО “Первый МГМУ им. И.М. Сеченова” МЗ РФ; заведующий отделом лучевых методов диагностики и лечения ФГБУ “Институт хирургии им. А.В. Вишневского” МЗ РФ, ГБОУ ВПО “Первый Московский государственный медицинский университет им. И.М. Сеченова” Минздрава России; ФГБУ “Институт хирургии им. А.В. Вишневского” Минздрава России, Москва, Россия

Диффузионно-взвешенные изображения (ДВИ) отражают свободное (броуновское) движение молекул воды. ДВИ позволяют проводить как качественный, так и количественный анализ изображений. В последние годы благодаря ряду технических достижений ДВИ все чаще стали применять для исследования экстракраниальной патологии, в том числе при заболеваниях печени. В обзоре литературы отражены основные принципы ДВИ, область их применения при очаговой патологии печени, результаты работ, изучающих возможность применения ДВИ в дифференциальной диагностике очаговых образований печени, оценке ответа опухоли на химиотерапию и местное лечение.

Ключевые слова:
диффузионно-взвешенные изображения, печень, очаговое поражение печени, дифференциальная диагностика, diffusion-weighted imaging, liver, focal liver lesions, differential diagnosis

Литература:
1.Demir O.I., Obuz F., Sağol O., Dicle O. Contribution of diffusion-weighted MRI to the differential diagnosis of hepatic masses. Diagn. Interv. Radiol. 2007; 13 (2): 81-86.
2.Chandarana H., Taouli B. Diffusion and perfusion imaging of the liver. Eur. J. Radiol. 2010; 76 (3): 348-358.
3.Semelka R.C., Martin D.R., Balci C., Lance T. Focal liver lesions: comparison of dual-phase CT and multisequence multiplanar MR imaging including dynamic gadolinium enhancement. J. Magn. Reson. Imaging. 2001; 13 (3): 397-401.
4.Galea N., Cantisani V., Taouli B. Liver lesion detection and characterization: role of diffusion-weighted imaging. J. Magn. Reson. Imaging. 2013; 37 (6): 1260-1276.
5.Le Bihan D., Breton E., Lallemand D. et al. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology. 1986; 161 (2): 401-407.
6.Schaefer P.W., Grant P.E., Gonzalez R.G. Diffusionweighted MR imaging of the brain. Radiology. 2000; 217 (2): 331-345.
7.Koh D.M., Collins D.J. Diffusion-weighted MRI in the body: applications and challenges in oncology. Am. J. Roentgenol. 2007; 188 (6): 1622-1635.
8.Kanematsu M., Goshima S., Watanabe H. et al. Diffusion/perfusion MR imaging of the liver: practice, challenges, and future. Magn. Reson. Med. Sci. 2012; 11 (3): 151-161.
9.Qayyum A. Diffusion-weighted imaging in the abdomen and pelvis: concepts and applications. Radiographics. 2009; 29 (6): 1797-1810.
10.Taouli B., Koh D.M. Diffusion-weighted MR imaging of the liver. Radiology. 2010; 254 (1): 47-66.
11.Акчурина Э.Д. Диффузионно-взвешенные изображения в комплексной лучевой диагностике очаговых поражений печени: Дис. ... канд. мед. наук. М., 2011. 24 с.
12.Papanikolaou N., Gourtsoyianni S., Yarmenitis S. et al. Comparison between two-point and four-point methods for quantification of apparent diffusion coefficient of normal liver parenchyma and focal lesions. Value of normalization with spleen. Eur. J. Radiol. 2010; 73 (2): 305-309.
13.Goshima S., Kanematsu M., Kondo H. et al. Diffusionweighted imaging of the liver: optimizing b value for the detection and characterization of benign and malignant hepatic lesions. J. Magn. Reson. Imaging. 2008; 28 (3): 691-697.
14.Aslan K., Danaci M., Polat A.V. et al. Can a b value of 500 be substituted for a b value of 1000 in the characterization of focal liver lesions? Abdom. Imaging. 2014; 39 (2): 300-309.
15.Kandpal H., Sharma R., Madhusudhan K.S., Kapoor K.S. Respiratory-triggered versus breath-hold diffusionweighted MRI of liver lesions: comparison of image quality and apparent diffusion coefficient values. Am. J. Roentgenol. 2009; 192 (4): 915-922.
16.Kim S.Y., Lee S.S., Byun J.H. et al. Malignant hepatic tumors: short-term reproducibility of apparent diffusion coefficients with breath-hold and respiratory-triggered diffusion-weighted MR imaging. Radiology. 2010; 255 (3): 815-823.
17.Chiu F.Y., Jao J.C., Chen C.Y. et al. Effect of intravenous gadolinium-DTPA on diffusion-weighted magnetic resonance images for evaluation of focal hepatic lesions. J. Comput. Assist. Tomogr. 2005; 29 (2): 176-180.
18.Choi J.S., Kim M.J., Choi J.Y. et al. Diffusion-weighted MR imaging of liver on 3.0-Tesla system: effect of intravenous administration of gadoxetic acid disodium. Eur. Radiol. 2010; 20 (5): 1052-1060.
19.Benndorf M., Schelhorn J., Dietzel M. et al. Diffusion weighted imaging of liver lesions suspect for metastases: Apparent diffusion coefficient (ADC) values and lesion contrast are independent from Gd-EOB-DTPA administration. Eur. J. Radiol. 2012; 81 (8): e849-е853.
20.Muhi A., Ichikawa T., Motosugi U. et al. Diffusion- and T2-weighted MR imaging of the liver: effect of intravenous administration of gadoxetic acid disodium. Magn. Reson. Med. Sci. 2012; 11 (3): 185-191.
21.Bruegel M., Gaa J., Waldt S. et al. Diagnosis of hepatic metastasis: comparison of respiration-triggered diffusionweighted echo-planar MRI and five t2-weighted turbo spin-echo sequences. Am. J. Roentgenol. 2008; 191 (5): 1421-1429.
22.Parikh T., Drew S.J., Lee V.S. et al. Focal liver lesion detection and characterization with diffusion-weighted MR imaging: comparison with standard breath-hold T2-weighted imaging. Radiology. 2008; 246 (3): 812-822.
23.Zech C.J., Herrmann K.A., Dietrich O. et al. Black-blood diffusion-weighted EPI acquisition of the liver with parallel imaging: comparison with a standard T2-weighted sequence for detection of focal liver lesions. Invest. Radiol. 2008; 43 (4): 261-266.
24.Kim T., Murakami T., Takahashi S. et al. Diffusion-weighted single-shot echoplanar MR imaging for liver disease. Am. J. Roentgenol. 1999; 173 (2): 393-398.
25.Taouli B., Vilgrain V., Dumont E. et al. Evaluation of liver diffusion isotropy and characterization of focal hepatic lesions with two single-shot echo-planar MR imaging sequences: prospective study in 66 patients. Radiology. 2003; 226 (1): 71-78.
26.Demir O.I., Obuz F., Sağol O., Dicle O. Contribution of diffusion-weighted MRI to the differential diagnosis of hepatic masses. Diagn. Interv. Radiol. 2007; 13 (2): 81-86.
27.Bruegel M., Holzapfel K., Gaa J. et al. Characterization of focal liver lesions by ADC measurements using a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging technique. Eur. Radiol. 2008; 18 (3): 477-485.
28.Gourtsoyianni S., Papanikolaou N., Yarmenitis S. et al. Respiratory gated diffusion-weighted imaging of the liver: value of apparent diffusion coefficient measurements in the differentiation between most commonly encountered benign and malignant focal liver lesions. Eur. Radiol. 2008; 18 (3): 486-492.
29.Miller F.H., Hammond N., Siddiqi A.J. et al. Utility of diffusion-weighted MRI in distinguishing benign and malignant hepatic lesions. J. Magn. Reson. Imaging. 2010; 32 (1): 138-147.
30.Testa M.L., Chojniak R., Sene L.S. et al. Is DWI/ADC a useful tool in the characterization of focal hepatic lesions suspected of malignancy? PLoS One. 2014; 9 (7): e101944.
31.Holzapfel K., Bruegel M., Eiber M. et al. Characterization of small (≤10 mm) focal liver lesions: value of respiratorytriggered echo-planar diffusion-weighted MR imaging. Eur. J. Radiol. 2010; 76 (1): 89-95.
32.Koike N., Cho A., Nasu K. et al. Role of iffusion-weighted agnetic resonance imaging in the differential diagnosis of focal hepatic lesions. Wld J. Gastroenterol. 2009; 15 (46): 5805-5812.
33.Nam S.J., Park K.Y., Yu J.S. et al. Hepatic cavernous hemangiomas: relationship between speed of intratumoral enhancement during dynamic MRI and apparent diffusion coefficient on diffusion-weighted imaging. Korean J. Radiol. 2012; 13 (6): 728-735.
34.Sandrasegaran K., Akisik F.M., Lin C. et al. The value of diffusion-weighted imaging in characterizing focal liver masses. Acad. Radiol. 2009; 16 (10): 1208-1214.
35.Sutherland T., Steele E., van Tonder F., Yap K. Solid focal liver lesion characterization with apparent diffusion coefficient ratios. J. Med. Imaging Radiat. Oncol. 2014; 58 (1): 32-37.
36.Onur M.R., Çiçekçi M., Kayalı A. et al. The role of ADC measurement in differential diagnosis of focal hepatic lesions. Eur. J. Radiol. 2012; 81 (3): e171-e176.
37.Latif M.A., Hawary G.E., Badrawy A.E., Alfy H.E. The role of MR diffusion in differentiation of malignant and benign hepatic focal lesions. Egypt J. Radiol. Nucl. Medicine. 2014; 45 (2): 299-308.
38.Agnello F., Ronot M., Valla D.C. et al. High-b-value diffusion-weighted MR imaging of benign hepatocellular lesions: quantitative and qualitative analysis. Radiology. 2012; 262 (2): 511-519.
39.Schmid-Tannwald C., Jiang Y., Dahi F. et al. Diffusionweighted MR imaging of focal liver lesions in the left and rightlobes: is there a difference in ADC values? Acad. Radiol. 2013; 20 (4): 440-445.
40.Hardie A.D., Naik M., Hecht E.M. et al. Diagnosis of liver metastases: value of diffusion-weighted MRI compared with gadolinium-enhanced MRI. Eur. Radiol. 2010; 20 (6): 1431-1441.
41.Kenis C., Deckers F., De Foer B. et al. Diagnosis of liver metastases: can diffusion-weighted imaging (DWI) be used as a stand alone sequence? Eur. J. Radiol. 2012; 81 (5): 1016-1023.
42.Eiber M., Fingerle A.A., Brügel M. et al. Detection and classification of focal liver lesions in patients with colorectal cancer: retrospective comparison of diffusion-weighted MR imaging and multi-slice CT. Eur. J. Radiol. 2012; 81 (4): 683-691.
43.Holzapfel K., Reiser-Erkan C., Fingerle A.A. et al. Com parison of diffusion-weighted MR imaging and multidetectorrow CT in the detection of liver metastases in patients operated for pancreatic cancer. Abdom. Imaging. 2011; 36 (2): 179-184.
44.Koh D.M., Brown G., Riddell A.M. et al. Detection of colorectal hepatic metastases using MnDPDP MR imaging and diffusion-weighted imaging (DWI) alone and in combination. Eur. Radiol. 2008; 18 (5): 903-910.
45.Koh D.M., Collins D.J., Wallace T. et.al. Combining diffusion-weighted MRI with Gd-EOB-DTPA-enhanced MRI improves the detection of colorectal liver metastases. Br. J. Radiol. 2012; 85 (1015): 980-989.
46.Holzapfel K., Eiber M.J., Fingerle A.A. et al. Detection, classification, and characterization of focal liver lesions: Value of diffusion-weighted MR imaging, gadoxetic acidenhanced MR imaging and the combination of both methods. Abdom. Imaging. 2012; 37 (1): 74-82.
47.Löwenthal D., Zeile M., Lim W.Y. et al. Detection and characterization of focal liver lesions in colorectal carcinoma patients: comparison of diffusion-weighted and Gd-EOB-DTPA enhanced MR imaging. Eur. Radiol. 2011; 21 (4): 832-840.
48.Haratake J., Takeda S., Kasai T. et al. Predictable factors for estimating prognosis of patients after resection of hepatocellular carcinoma. Cancer. 1993; 72 (4): 1178-1183.
49.Nzeako U.C., Goodman Z.D., Ishak K.G. Comparison of tumor pathology with duration of survival of North American patients with hepatocellular carcinoma. Cancer. 1995; 76 (4): 579-588.
50.De Carlis L., Giacomoni A., Lauterio A. et al. Liver transplantation for hepatocellular cancer: should the current indication criteria be changed? Transpl. Int. 2003; 16 (2): 115-122.
51.Bhattacharjya S., Bhattacharjya T., Quaglia A. et al. Liver transplantation in cirrhotic patients with small hepatocellular carcinoma: an analysis of pre-operative imaging, explant histology and prognostic histologic indicators. Dig. Surg. 2004; 21 (2): 152-159.
52.Pérez-Saborido B., de los Galanes S.J., Menéu-Díaz J.C. et al. Tumor recurrence after liver transplantation for hepatocellular carcinoma: recurrence pathway and prognostic factors. Transplant. Proc. 2007; 39 (7): 2304-2307.
53.Oishi K., Itamoto T., Amano H. et al. Clinicopathologic features of poorly differentiated hepatocellular carcinoma. J. Surg. Oncol. 2007; 95 (4): 311-316.
54.Okusaka T., Okada S., Ueno H. et al. Satellite lesions in patients with small hepatocellular carcinoma with reference to clinicopathologic features. Cancer. 2002; 95 (9): 1931-1937.
55.Nasu K., Kuroki Y., Tsukamoto T. et al. Diffusion-weighted imaging of surgically resected hepatocellular carcinoma: imaging characteristics and relationship among signal intensity, apparent diffusion coefficient, and histo pathologic grade. Am. J. Roentgenol. 2009; 193 (2): 438-444.
56.Nishie A., Tajima T., Asayama Y. et al. Diagnostic performance of apparent diffusion coefficient for predicting histological grade of hepatocellular carcinoma. Eur. J. Radiol. 2011; 80 (2): e29-e33.
57.Piana G., Trinquart L., Meskine N. et al. New MR imaging criteria with a diffusion-weighted sequence for the diagnosis of hepatocellular carcinoma in chronic liver diseases. J. Hepatol. 2011; 55 (1): 126-132.
58.Muhi A., Ichikawa T., Motosugi U. et al. High-b-value diffusion-weighted MR imaging of hepatocellular lesions: estimation of grade of malignancy of hepatocellular carcinoma. J. Magn. Reson. Imaging. 2009; 30 (5): 1005-1011.
59.Asayama Y., Yoshimitsu K., Nishihara Y. et al. Arterial blood supply of hepatocellular carcinoma and histologic grading: radiologic-pathologic correlation. Am. J. Roentgenol. 2008; 190 (1): W28-34.
60.Vandecaveye V., De Keyzer F., Verslype C. et al. Diffusionweighted MRI provides additional value to conventional dynamic contrast-enhanced MRI for detection of hepatocellular carcinoma. Eur. Radiol. 2009; 19 (10): 2456-2466.
61.Mori Y., Tamai H., Shingaki N. et al. Detection of hypervascular hepatocellular carcinoma with non-enhanced magnetic resonance imaging including diffusion-weighted imaging. GHR. 2013; 2 (3): 473-478.
62.Xu P.J., Yan F.H., Wang J.H. et al. Added value of breathhold diffusion-weighted MRI in detection of small hepatocellular carcinoma lesions compared with dynamic contrastenhanced MRI alone using receiver operating characteristic curve analysis. J. Magn. Reson. Imaging. 2009; 29 (2): 341-349.
63.Zhao X.T., Li W.X., Chai W.M., Chen K.M. Detection of small hepatocellular carcinoma using gadoxetic acidenhanced MRI: Is the addition of diffusion-weighted MRI at 3.0T beneficial? J. Dig. Dis. 2014; 15 (3): 137-145.
64.Cui Y., Zhang X.P., Sun Y.S. et al. Apparent diffusion coefficient: potential imaging biomarker for prediction and early detection of response to chemotherapy in hepatic metastases. Radiology. 2008; 248 (3): 894-900.
65.Koh D.M., Scurr E., Collins D. et al. Predicting response of colorectal hepatic metastasis: value of pretreatment apparent diffusion coefficients. Am. J. Roentgenol. 2007; 188 (4): 1001-1008.
66.Marugami N., Tanaka T., Kitano S. et al. Early detection of therapeutic response to hepatic arterial infusion chemotherapy of liver metastases from colorectal cancer using diffusion-weighted MR imaging. Cardiovasc. Intervent. Radiol. 2009; 32 (4): 638-646.
67.Sangiovanni A., Del Ninno E., Fasani P. et al. Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance. Gastroenterology. 2004; 126 (4):1005-1014.
68.Chung J.C., Naik N.K., Lewandowski R.J. et al. Diffusionweighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization. Wld J. Gastroenterol. 2010; 16 (25): 3161-3167.
69.Yuan Z., Ye X.D., Dong S. et al. Role of magnetic resonance diffusion-weighted imaging in evaluating response after chemoembolization of hepatocellular carcinoma. Eur. J. Radiol. 2010; 75 (1): e9-е14.
70.Mannelli L., Kim S., Hajdu C.H. et al. Serial diffusionweighted MRI in patients with hepatocellular carcinoma: Prediction and assessment of response to transarterial chemoembolization. Preliminary experience. Eur. J. Radiol. 2013; 82 (4): 577-582.
71.Mungai F., Pasquinelli F., Mazzoni L.N. et al. Diffusionweighted magnetic resonance imaging in the prediction and assessment of chemotherapy outcome in liver metastases. Radiol. Med. 2014; 119 (8): 625-633.
72.Dudeck O., Zeile M., Wybranski C. et al. Early prediction of anticancer effects with diffusion-weighted MR imaging in patients with colorectal liver metastases following selective internal radiotherapy. Eur. Radiol. 2010; 20 (11): 2699-2706.
73.Goshima S., Kanematsu M., Kondo H. et al. Evaluating local hepatocellular carcinoma recurrence posttranscatheter arterial chemoembolization: is diffusionweighted MRI reliableas an indicator? J. Magn. Reson. Imaging. 2008; 27 (4): 834-839.
74.Yu J.S., Kim J.H., Chung J.J., Kim K.W. Added value of diffusion-weighted imaging in the MRI assessment of perilesional tumor recurrence after hemoembolization of hepatocellular carcinomas. J. Magn. Reson. Imaging. 2009; 30 (1): 153-160.

Diffusion-Weighted Imaging of Focal Liver Lesions: Literature Review

Lomovtseva K. K., Karmazanovsky G.G.

Diffusion-weighted imaging (DWI) reflects Brownian motion of water molecules. DWI provides both qualitative and quantitative image analysis. In recent years, with technical advances, DWI has been increasingly applied to extracranial pathology, including liver diseases. In this article the basic principles of DWI, clinical application, studies of DWI in the differential diagnosis of focal liver lesions, evaluation of tumor response to chemotherapy and local treatment are discussed.

Keywords:
диффузионно-взвешенные изображения, печень, очаговое поражение печени, дифференциальная диагностика, diffusion-weighted imaging, liver, focal liver lesions, differential diagnosis

ООО Издательский дом ВИДАР-М, 2016