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Оценка качества жизни больных, оперированных по поводу злокачественных новообразований поджелудочной железы и периампулярной зоны. Систематический обзор

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   Цель. Анализ актуальных методов оценки качества жизни пациентов, проходящих хирургическое лечение по поводу рака поджелудочной железы и периампулярной зоны, изучение влияния хирургического лечения и послеоперационных осложнений на качество жизни.   Материал и методы. Проведен систематический обзор литературы, содержащейся в электронных базах данных MEDLINE, Embase и e-Library, за 2015–2022 гг. Методология систематического обзора отражена в протоколе исследования, составленного в соответствии с рекомендациями PRISMA.   Результаты. В систематический обзор вошли 26 исследований, включавших 4937 пациентов, отвечающих критериям включения. Были изучены такие характеристики исследований, как дизайн и задачи, опросные формы, методы хирургического и лекарственного лечения, периодичность опроса и методика сбора данных, риск систематической ошибки и др.   Заключение. При выборе опросной формы большинство авторов отдавали предпочтение EORTC QLQ-C30 и EORTC QLQ-PAN26. Даже наиболее сложные операции, такие как панкреатодуоденальная резекция и панкреатэктомия, позволяют добиться удовлетворительного качества жизни. Во многих актуальных исследованиях присутствуют методологические недостатки, увеличивающие риск систематической ошибки и уменьшающие достоверность полученных данных. Необходимо дальнейшее изучение качества жизни пациентов этой категории, стандартизация оптимальных принципов и методологии проведения подобных исследований, в частности, в отечественном здравоохранении.

Ключевые слова:
поджелудочная железа, периампулярная зона, качество жизни, злокачественные новообразования, опросная форма, хирургическое лечение, pancreas, periampullary area, quality of life, malignant neoplasms, survey form, surgical treatment

Литература:
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Assessment of quality of life in patients after surgery for pancreatic and periampullary malignancies. Systematic review

   Aim. To analyze the current methods of life quality assessment in patients undergoing surgical treatment for pancreatic and periampullary cancer, to study the influence of surgical treatment and postoperative complications on the quality of life.   Materials and methods. The study involves a systematic review of the literature available in MEDLINE, Embase and e-Library electronic databases for 2015–2022. The methodology of the systematic review is reflected in the study protocol, designed according to PRISMA guidelines.   Results. The systematic review embraces 26 studies including 4937 patients met the inclusion criteria. The present study examines design and objectives, survey forms, methods of surgical interventions and drug treatment, survey frequency and data collection methodology, risk of systematic error, etc.   Conclusion. When choosing a survey form, most authors favored EORTC QLQ-C30 and EORTC QLQ-PAN26. Even the most complex surgeries such as pancreaticoduodenal resection and pancreatectomy can provide a satisfactory quality of life. Many current studies appear methodologically-challenged thereby increasing the risk of systematic error and reducing the reliability of the data. The quality of life of patients in this category is to be further investigated, the optimal principles and methodology of such studies are to be standardized, in particular, in Russian healthcare system.

Keywords:
поджелудочная железа, периампулярная зона, качество жизни, злокачественные новообразования, опросная форма, хирургическое лечение, pancreas, periampullary area, quality of life, malignant neoplasms, survey form, surgical treatment