Медицинская литература. Новинки

 

 

 

 

 

 

Диагностика и лечение аутоиммунного панкреатита (обзор литературы)

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Аутоиммунный панкреатит впервые описан в 1961 г. как “первичный воспалительный склероз поджелудочной железы”. В последующих сообщениях это заболевание описывали как лимфоплазмоцитарный склерозирующий панкреатит, хронический склерозирующий панкреатит, неалкогольный протоково-деструктивный панкреатит, воспалительная псевдоопухоль поджелудочной железы и др. Концепция аутоиммунного панкреатита была предложена Yoshida и соавт. в 1995 г. Проведены многочисленные клинические, серологические, радиологические и патологоанатомические исследования. Для облегчения клинического ведения больных аутоиммунным панкреатитом были введены диагностические критерии, выявлены серологические маркеры и патологические особенности. Также были получены данные, указывающие на то, что аутоиммунный панкреатит является частью новой клинико-патологической нозологической единицы - IgG4-ассоциированной аутоиммунной болезни. Важным остается вопрос хирургического лечения аутоиммунного панкреатита, которое выполняется чаще всего при подозрении злокачественного новообразования поджелудочной железы. Таким образом, аутоиммунный панкреатит представляет собой актуальную проблему современной медицины, которая требует дальнейшего изучения.

Ключевые слова:
поджелудочная железа, аутоиммунный панкреатит, диагностика, единые международные диагностические критерии, прогноз, рецидив, глюкокортикостероиды, хирургическое лечение, pancreas, autoimmune pancreatitis, diagnosis, international consensus diagnostic criteria for autoimmune pancreatitis, prognosis, recurrence, steroid therapy, surgical treatment

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Diagnosis and Treatment of Autoimmune Pancreatitis. (Review)

The autoimmune pancreatitis was described in 1961 as “a primary inflammatory sclerosis of the pancreas”. Subsequent reports have described this disease as lymphoplasmacytic sclerosing pancreatitis, chronic sclerosing pancreatitis, nonalcoholic duct-destructive pancreatitis, inflammatory pseudotumor of pancreas, etc. The concept of autoimmune pancreatitis was proposed by Yoshida et al. in 1995. Numerous clinical, serological, radiological and pathological studies were conducted. Diagnostic criteria, serological markers and pathological features were introduced to facilitate autoimmune pancreatitis patients management. Also data were obtained indicating autoimmune pancreatitis as a part of new clinicopathological entity - IgG4-related sclerosing disease. Important issue is surgical treatment of autoimmune pancreatitis which is performed in case of suspected pancreatic cancer as a rule. Thus, autoimmune pancreatitis is an actual problem of modern medicine and requires further study.

Keywords:
поджелудочная железа, аутоиммунный панкреатит, диагностика, единые международные диагностические критерии, прогноз, рецидив, глюкокортикостероиды, хирургическое лечение, pancreas, autoimmune pancreatitis, diagnosis, international consensus diagnostic criteria for autoimmune pancreatitis, prognosis, recurrence, steroid therapy, surgical treatment