Медицинская литература. Новинки

 

 

 

 

 

 

Роль системной терапии при локализованном раке поджелудочной железы (обзор литературы)

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Несмотря на все достижения современной клинической и хирургической онкологии, результаты лечения локализованного (раннего) рака поджелудочной железы назвать удовлетворительными сложно. Тем не менее определенных успехов все же удалось добиться и у этой прогностически крайне неблагоприятной группы больных. В статье рассмотрена эволюция системной лекарственной терапии, а также новые концепции в лечении погранично-резектабельного и резектабельного рака поджелудочной железы. Проводимая противоопухолевая терапия позволила значимо улучшить результаты лечения пациентов, при этом обладая приемлемым профилем токсичности. Однако, несмотря на достигнутые результаты, необходимы дальнейшие исследования для повышения эффективности лечения.

Ключевые слова:
поджелудочная железа, рак, адъювантная терапия, неоадъювантная терапия, резектабельность, отдаленные результаты, выживаемость, pancreas, cancer, adjuvant therapy, neoadjuvant therapy, resectability, long-term results, survival

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The role of systemic therapy in localized pancreatic cancer (review)

The results of treatment of localized (early) pancreatic cancer are unsatisfactory despite all achievements of modern clinical and surgical oncology. Nevertheless, certain success was achieved even in these extremely unfavorable patients regarding their prognosis. The authors analyzed evolution of adjuvant therapy, as well as new concepts in the treatment of borderline resectable and resectable pancreatic cancer. Modern anticancer therapy with acceptable toxicity profile significantly improved the outcomes. However, further research is needed to improve the effectiveness of treatment despite favorable current results.

Keywords:
поджелудочная железа, рак, адъювантная терапия, неоадъювантная терапия, резектабельность, отдаленные результаты, выживаемость, pancreas, cancer, adjuvant therapy, neoadjuvant therapy, resectability, long-term results, survival