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Роль гормонов щитовидной железы и потребления иода в онтопатогенезе различных заболеваний: акцент на взаимодействиях с глюкокортикоидами и веществами, нарушающими эндокринную регуляцию

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Представлен библиографический мини-обзор об участии гормонов щитовидной железы в явлениях импринтинга/программирования во время перинатального развития во взаимодействии с глюкокортикоидами и некоторыми химическими агентами, загрязняющими окружающую среду и нарушающими эндокринную регуляцию, с увеличением предрасположенности к ряду заболеваний во взрослом состоянии и даже в старости. Кроме того, зарегистрировано недостаточное содержание йода в продаваемых в аптеках лекарственных препаратах с витаминами и микроэлементами для потребления во время беременности и грудного вскармливания, что вносит определенный вклад в более высокий риск субклинического гипотиреоза. Наконец, сделана попытка привлечь внимание к возможному существованию пока еще не идентифицированного метаболического ингибитора, который может нарушать регуляцию функций щитовидной железы при старении.

Ключевые слова:
щитовидная железа, глюкокортикоиды, йод, онтогенез, окружающая среда, thyroid gland, glucocorticoids, iodine, ontogeny, environment

Литература:
1.1. Godfrey KM, Barker DJP. Fetal programming and adult health. Public Health Nutr. 2001;4:611-624. doi: 10.1079/PHN2001145.
2.2. Fowden AL, Giussani DA, Forhead AJ. Intrauterine programming of physiological systems: causes and consequences. Physiology (Bethesda). 2006;21:29-37. doi: 10.1152/physiol.00050.2005.
3.3. Harris A, Seckl J. Glucocorticoids, prenatal stress and the programming of disease. Horm Behav. 2011;59:279-289. doi: 10.1016/j.yhbeh.2010.06.007.
4.4. Goudochnikov VI. Disorders in adult state after perinatal excessive exposure to glucocorticoids. In: 6. Congresso de Stress da ISMA-BR. Porto Alegre, 2006.
5.5. Goudochnikov VI, Kroth EAF. The role of corticoids in fetal/early programming of metabolic syndrome. Diabetes Clinica (Sao Paulo). 2008;12(1):55-59.
6.6. Robson H, Siebler T, Shalet SM, Williams GR. Interactions between GH, IGF-I, glucocorticoids, and thyroid hormones during skeletal growth. Pediatr Res. 2002;52:137-147. doi: 10.1203/01.PDR.0000023494.70201.1C.
7.7. Heitzer MD, Wolf IM, Sanchez ER, et al. Glucocorticoid receptor physiology. Rev Endocr Metab Disord. 2007;8:321-330. doi: 10.1007/s11154-007-9059-8.
8.8. Munoz A, Bernal J. Biological activities of thyroid hormone receptors. Eur J Endocrinol. 1997;137:433-445.
9.9. Федотов В.П., Баранова И.Н., Гудошников В.И. Гормональная регуляция биосинтеза белка в культурах клеток печени // Проблемы эндокринологии. - 1990. - Т.36. - №4 - С. 35-42.
10.10. Fedotov VP, Mamayeva TV, Gudoshnikov VI. Age-specific effects of insulin on the secretion of somatotropic hormone. Bulletin of Experimental Biology and Medicine. 1994;117:307-310.
11.11. Morreale de Escobar G, Obregon MJ, Escobar del Rey F. Role of thyroid hormone during early brain development. Eur J Endocrinol. 2004;151:U25-U37. doi: 10.1530/eje.0.151U025.
12.12. Smallridge RC, Ladenson PW. Hypothyroidism in pregnancy: consequences to neonatal health. J Clin Endocrinol Metab. 2001;86(6):2349-2353.
13.13. Berbel P, Obregon MJ, Bernal J, et al. Iodine supplementation during pregnancy: a public health challenge. Trends Endocrinol Metab. 2007;18(9):338-343. doi: 10.1016/j.tem.2007.08.009.
14.14. Morreale de Escobar G, Obregon MJ, Escobar del Rey F. Clinical perspective: Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia? J Clin Endocrinol Metab. 2000;85(11):3975-3987. doi: 10.1210/jc.85.11.3975.
15.15. Delange F. Optimal iodine nutrition during pregnancy, lactation and the neonatal period. Int J Endocrinol Metab. 2004;2:1-12.
16.16. Nogami H, Jokose T, Tachibana T. Regulation of growth hormone expression in fetal rat pituitary gland by thyroid or glucocorticoid hormone. Am J Physiol. 1995;268(2 Pt 1):E262-E267.
17.17. Kuhn ER, Geris KL, Van der Geyten S, et al. Inhibition and activation of the thyroidal axis by the adrenal axis in vertebrates. Comp Biochem Physiol A Mol Integr Physiol. 1998;120(1):169-174.
18.18. Mizokami T, Li AW, El-Kaissi S, Wall JR. Stress and thyroid autoimmunity. Thyroid. 2004;14(12):1047-1055.
19.19. Taylor AD, Flower RJ, Buckingham JC. Dexamethasone inhibits the release of TSH from the rat anterior pituitary gland in vitro by mechanisms dependent on de novo protein synthesis and lipocortin 1. J Endocrinol. 1995;147(3):533-544.
20.20. Van Buul-Offers SC, Smink JJ, Gresnigt R, et al. Thyroid hormone, but not parathyroid hormone, partially restores glucocorticoid-induced growth retardation. Pediatr Nephrol. 2005;20(3):335-341. doi: 10.1007/s00467-004-1690-y.
21.21. Dorshkind K, Horseman ND. Anterior pituitary hormones, stress, and immune system homeostasis. Bioessays. 2001;23(3):288-294.
22.22. Blazer S, Moreh-Waterman Y, Miller-Lotan R, et al. Maternal hypothyroidism may affect fetal growth and neonatal thyroid function. Obstet Gynecol. 2003;102(2):232-241.
23.23. Glinoer D. The systematic screening and management of hypothyroidism and hyperthyroidism during pregnancy. Trends Endocrinol Metab. 1998;9(10):403-411.
24.24. Bakke J, Lawrence N, Wilber JF. The late effects of neonatal hyperthyroidism upon the hypothalamic - pituitary - thyroid axis in the rat. Endocrinology. 1974;95:406-411. doi: 10.1210/endo-95-2-406.
25.25. Ooka H, Fujita S, Yoshimoto E. Pituitary-thyroid activity and longevity in neonatally thyroxine-treated rats. Mech Ageing Dev. 1983;22(2):113-120. doi: 10.1016/0047-6374(83)90104-5.
26.26. Kajantie E, Phillips DI, Osmond C, et al. Spontaneous hypothyroidism in adult women is predicted by small body size at birth and during childhood. J Clin Endocrinol Metab. 2006;91(12): 4953-4956.
27.27. Hertoghe T. The “multiple hormone deficiency” theory of aging: is human senescence caused mainly by multiple hormone deficiencies. Ann N Y Acad Sci. 2005;1057:448-465. doi: 10.1111/j.1749-6632.2005.tb06150.x.
28.28. Fabris N. Neuroendocrine - immune interactions: a theoretical approach to aging. Arch Gerontol Geriatr. 1991;12(2-3):219-230. doi: 10.1016/0167-4943(91)90029-P.
29.29. Knudsen N, Laurberg P, Rasmussen LB, et al. Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. J Clin Endocrinol Metab. 2005;90(7):4019-4024.
30.30. Kirkegaard C, Faber J. The role of thyroid hormones in depression. Eur J Endocrinol. 1998;138:1-9.
31.31. Pierpaoli W, Baroni C, Fabris N, Sorkin E. Hormones and immunological capacity. II. Reconstitution of antibody production in hormonally deficient mice by somatotropic hormone, thyrotropic hormone and thyroxin. Immunology.1969;16(2):217-230.
32.32. Goudochnikov VI. Glucocorticoid programming: prenatal or perinatal? Journal of Developmental Origins of Health and Disease. 2009;1:S182-S183.
33.33. Bernal J. Thyroid hormones and brain development. Horm Brain Behav. 2002;4:543-587.
34.34. Porterfield SP, Hendrich CE. The role of thyroid hormones in prenatal and neonatal neurological development: current perspectives. Endocr Rev. 1993;14(1):94-106.
35.35. Yun AY, Lee PY, Bazar KA, et al. The incorporation of iodine in thyroid hormone may stem from its role as a prehistoric signal of ecologic opportunity: an evolutionary perspective and implications for modern diseases. Medical Hypotheses. 2005;65(4): 804-810. doi: 10.1016/j.mehy.2005.02.007.
36.36. Goudochnikov VI. Environment-polluting agents as endocrine disruptors: possible amplification of a concept. In: 4. Forum Nacional do Meio Ambiente. Santa Rosa; 2006.
37.37. Boas M, Feldt-Rasmussen U, Skakkebaek NE, Main KM. Environmental chemicals and thyroid function. Eur J Endocrinol. 2006;154(5):599-611.
38.38. Langer P. Persistent organochlorinated pollutants (POPs) and human thyroid. Endocr Regul. 2005;39(2):53-68.
39.39. Zoeller RT. Polychlorinated biphenils as disruptors of thyroid hormone action. In: Robertson LW, Hansen LG, editors. PCBs: Recent Advances in Environmental Toxicology and Health Effects. Lexington: University Press of Kentucky; 2001, p.265-271.
40.40. Kirk AB, Martinelango PK, Tian K, et al. Perchlorate and iodide in dairy and breast milk. Environ Sci Technol. 2005;39(7):2011-2017.
41.41. Denckla WD. Role of pituitary and thyroid glands in the decline of minimal O2 consumption with age. J Clin Invest. 1974;53(2): 572-581. doi: 10.1172/JCI107592.
42.42. Патент РФ на изобретение № 1624327. Гудошников В.И., Абрамова В.В., Федотов В.П. Способ препаративного гель-электрофоретического разделения гипофизарных белков.
43.43. Goudochnikov VI. Metabolic syndrome, sedentarism and hypophyseal inhibitor. FIEP Bulletin (Foz do Iguacu). 2005;75:179.
44.44. Goudochnikov VI. Role of hormones in perinatal and early postnatal development: possible contribution to programming/imprinting phenomena. Ontogenez. 2015;46(5):285-294.
45.45. Goudochnikov VI, Prokhorov LY. Ontogenetic role of somatolactogens and related peptides as antistress hormones. Gerontologiya. 2014;2:143-156.
46.46. Prokhorov LY, Goudochnikov VI. Ontogenetic role of melatonin and neuroactive steroids as antistress hormones. Gerontologiya. 2014;2:157-170.

Role of thyroid hormones and iodine consumption in the ontopathogeny of various diseases: focus on interactions with glucocorticoids and some endocrine disruptors

Bibliographic mini-review is presented on participation of thyroid hormones in programming / imprinting phenomena during perinatal development, as well as on their interactions with glucocorticoids and some environment-polluting endocrine disruptors causing an increase in predisposition to several diseases in adult state and even in senile period. Besides, insufficient content of iodine was registered in pharmaceutical preparations with vitamins and microelements for consumption during gestation and lactation, contributing to higher risk of subclinical hypothyroidism. Finally, an attempt was made to attract more attention to possible existence of unidentified metabolic inhibitor that can interfere in the regulation of thyroid functions in aging.

Keywords:
щитовидная железа, глюкокортикоиды, йод, онтогенез, окружающая среда, thyroid gland, glucocorticoids, iodine, ontogeny, environment