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Перспективы магнитно-резонансной спектроскопии как метода диагностики в невропатологии

Н.А. Семенова*, Т.А. Ахадов**, С.Л. Ситников***, С.Д. Варфоломеев****
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Семенова Наталия Александровна – доктор биол. наук, ведущий научный сотрудник отдела динамики химических и биологических процессов Института химической физики им. Н.Н. Семенова РАН, Ахадов Толиб Абдуллаевич – доктор мед. наук, профессор, руководитель отдела лучевых методов диагностики НИИ неотложной детской хирургии и травматологии, Ситников Сергей Леонидович – студент физического факультета МГУ им. М. В. Ломоносова, Варфоломеев Сергей Дмитриевич – член-корр. РАН, директор Института биохимической физики им. Н.М. Эммануэля РАН.
Адрес для корреспонденции: Семенова Наталия Александровна: дбн, ведущий научный сотрудник отдела динамики химических и биологических процессов Института химической физики им. Н.Н. Семенова РАН. Москва 117321 ул. Осторовитянова

В обзоре обсуждаются возможности метода спектроскопии ядерного магнитного резонанса в диагностике и прогнозе заболеваний центральной нервной системы. Предлагается использование сигнала N-ацетиласпартата (NAA) в качестве маркера функционально полноценных нейронов. Приводятся данные о связи уровня NAA в структурах мозга с нарушениями биологических функций, сведения о метаболизме NAA и его роли в клетках нервной ткани.

Ключевые слова:
магнитно-резонансная спектроскопия, мозг, Nацетиласпартат, нейродегенерация.

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Perspectives of Magnetic Resonance Spectroscopy as the Method of Diagnostics in Neuropathology

N.А. Semenova, T.A. Akhadov, S.L. Sitnikov, S.D. Varfolomeev

In the review possibilities of a method of spectroscopy of a nuclear magnetic resonance in diagnostics and the prognosis of diseases of the central nervous system are discussed. Use of N-acetylaspartate (NAA) signal as a marker of functionally valid neurons is offered. The data about correlation of NAA level in structures of a brain with biological disfunctions, data on metabolism NAA and its role in neuronal cells is cited.

Keywords:
magnetic resonance spectroscopy, brain, N-acetylaspartate, neyrodegeneration.

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