Медицинская литература. Новинки

 

 

 

 

 

 

Применение йодсодержащих органических рентгеноконтрастных средств у больных с риском развития почечной недостаточности

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В статье рассмотрены механизмы возможного влияния йодированных органических неионных рентгеноконтрастных средств (РКС) на почки. Обсуждается правомерность использования для сравнения почечных эффектов РКС суррогатного параметра – уровня креатинина в сыворотке крови и клинически значимых параметров – частота проведения гемодиализа и частота госпитализации. Делается вывод, что неионные димерные РКС не безопаснее, а в ряде случае даже имеют потенциально более высокую нефротоксичность по сравнению с мономерными неионными РКС.

Ключевые слова:
рентгеноконтрастные средства, контраст-индуцируемая нефропатия

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Iodine Organic Roentgen Contrast Media use in Patients with Risk of Nephropathy

It has been considerated the mechanisms of iodine organic nonionic roentgen contrast media (RCM) kidneys action. Correct use of creatinine level or clinical endpoints need for dialysis or nedd for hospitalization for estimation of nefrotoxic effects of RCM. Concluded that nonionic dimeric RCM have not advantages versus monomeric nonionic RCM in view of their kidney safety

Keywords:
roentgen contrast media, contrast-induced nephropathy.