Медицинская литература. Новинки

 

 

 

 

 

 

ФАКТОРЫ СЕРДЕЧНО-СОСУДИСТОГО РИСКА, СВЯЗАННЫЕ С ФУНКЦИЕЙ ЭНДОТЕЛИЯ, ПРИ СУБКЛИНИЧЕСКОМ ГИПОТИРЕОЗЕ

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В ходе работы определяли параметры функции сосудистого эндотелия у больных с субклиническим гипотиреозом. В поперечное исследование были включены 39 пациентов с субклиническим гипотиреозом и 14 сопоставимых лиц контрольной группы. При субклиническом гипотиреозе выявлены достоверное снижение эндотелий-зависимой вазодилатации, повышение уровня эндотелина-1 и активности PAI-1, что позволяет сделать вывод о наличии эндотелиальной дисфункции. При субклиническом гипотиреозе выявлено повышение уровней общего холестерина и липопротеинов низкой плотности, положительно коррелирующие с уровнем ТТГ.

Ключевые слова:
субклинический гипотиреоз, эндотелиальная дисфункция, сердечно-сосудистый риск

Литература:
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Endothelium-related Cardiovascular Risk Factors in Subclinical Hypothyroidism

The aim of the study was to evaluate the endothelial function in patients with subclinical hypothyroidism. 39 patients and a control group of 14 matched persons group were included in cross-sectional research. In subclinical hypothyroid patients endothelium-dependent vasodilatation significantly decreased, while endothelin-1 and PAI-1 levels increased. Levels of total cholesterol and low-density lipoproteins were significantly higher in patients with subclinical hypothyroidism than in control group, and their positive correlation with TSH was revealed. These findings allow us to make a conclusion on presence of endothelial dysfunction and atherogenic dislipoproteinemia in patients with subclinical hypothyroidism.

Keywords:
subclinical hypothyroidism, endothelial dysfunction, cardiovascular risk