Медицинская литература. Новинки

 

 

 

 

 

 

Церебральный метаболизм при черепно-мозговой травме у детей

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Проведена МРтомография и МРспектроскопия мозга детей в остром периоде после черепно-мозговой травмы. По данным диагностической МРТ пациенты разделены на 3 группы: норма, легкий ушиб и тяжелый ушиб. Спектры зарегистрированы в неизмененном по данным МРТ сером веществе, белом веществе и гиппокампе. Статистически достоверное уменьшение уровня Nацетиласпартата (NAA) наблюдается только в сером веществе (у пациентов с легким и тяжелым ушибом на 8 и 16% соответственно). Уровень холинсодержащих соединений (Cho) достоверно увеличивается вследствие тяжелого ушиба в белом веществе, сером веществе и гиппокампе на 34, 26 и 18%, соответственно. Найдена корреляционная связь (коэффициент корреляции R = 0,74) между NAA и Cho при легком ушибе.

Ключевые слова:
магнитно-резонансная спектроскопия, черепно-мозговая травма, N-цетиласпартат, холин.

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Cerebral Metabolism of the Children with Traumatic Brain Injury

MR imaging and MR spectroscopy of brain in children under traumatic head injury were performed. According to diagnostic MRI, patients were classified into three groups norm, mild injury and severe injury. Spectra were registered in normal appearing gray matter, white matter and hippocampus. Statistically significant decrease of Nacetyl aspartate (NAA) level was observed in gray matter of patients with mild and severe injury (in 8% and 16% respectively). The level of choline containing compounds was reliably increased under severe injury in white matter, gray matter and hippocampus in 34%, 26% and 18% respectively. The correlation link (correlation coefficient R = 0.74) was found between NAA and Cho under mild injury.

Keywords:
magnetic resonance spectroscopy, traumatic brain injury, Nacetylaspartate, choline.