Медицинская литература. Новинки

 

 

 

 

 

 

Биохимические основы визуализации при позитронной эмиссионной томографии в онкологии. Часть 1

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Настоящая статья содержит обзор основных литературных данных, посвященных биохимическим основам клинического применения позитронной эмиссионной томографии - одной из наиболее перспективных технологий лучевой визуализации в онкологии. В первой части рассмотрены особенности биокинетики метаболических радиофармацевтических препаратов, таких как 18F-фтордезоксиглюкоза, радиомеченые маркеры липидного обмена 11С- и 18F-холин, 11C-ацетат, а также аналоги аминокислот 18F-дигидроксифенилаланин, 11С метионин, 18F-фторэтилтирозин, 11С-триптофан, 18F-флуцикловин. Кратко представлены результаты исследований, посвященных оценке эффективности, основные показания к применению, а также перспективные научные разработки в данной отрасли.

Ключевые слова:
ПЭТ/КТ, РФП, ФДГ, холин, ацетат, ДОФА, триптофан, ФЭТ, флуцикловин, PET/CT, radiopharmaceuticals, metabolic processes, aminoacid analogues, fluordeoxyglucose, choline, acetate, fluciclovine, DOPA, tryptophan, fluorethyltyrosine, thymidine

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Biochemical basics of imaging in positron emission tomography in oncology. Part 1

This article provides a literature overview of biochemical basics and the clinical application of positron emission tomography, one of the most promising technologies of nuclear imaging in oncology. In the first part we discuss the biokinetics of metabolic radiopharmaceuticals, such as 18F-fluorodeoxyglucose, radiolabeled markers of lipid metabolism 11C- and 18F-choline, 11C-acetate, as well as amino acids analogues - 18F-dihydroxyphenylalanine, 11C-methionine, 18F-fluoroe thyltyrosine, 11C-tryptophan, 18F-flucyclovine. This article includes results of scientific researches, that studied radiopharmaceuticals’ effectiveness in oncological practice. The main indications for use, as well as promising scientific developments in this industry are presented.

Keywords:
ПЭТ/КТ, РФП, ФДГ, холин, ацетат, ДОФА, триптофан, ФЭТ, флуцикловин, PET/CT, radiopharmaceuticals, metabolic processes, aminoacid analogues, fluordeoxyglucose, choline, acetate, fluciclovine, DOPA, tryptophan, fluorethyltyrosine, thymidine