Новости | Магазин | Журналы | Контакты | Правила | Доставка | |
Вход Регистрация |
Бесконтрастная МР-перфузия “меченых спинов артериальной крови” (“ASL-перфузия”) – это МР-технология качественной и количественной оценки перфузионных свойств тканей, основанная на маркировке спинов протонов артериальной крови радиочастотными импульсами и последующем их измерении при прохождении через зону интереса. Наибольший клинический опыт применения ASL-перфузии накоплен в диагностике заболеваний центральной нервной системы, однако в последние годы появились работы, показывающие эффективность использования данной методики в оценке перфузии скелетных мышц и диагностике опухолей мягких тканей.Представлены два клинических наблюдения (опухоль мягких тканей и посттравматические неопухолевые изменения), демонстрирующие возможности применения указанной методики для бесконтрастной оценки характера васкуляризации патологических изменений в мягких тканях бедра.
Ключевые слова:
опухоли мягких тканей, мультипараметрическая магнитно-резонансная томография, ASL-перфузия, soft tissue tumors, multiparametric magnetic resonance imaging, ASL-perfusion
Литература:
1.Lin C.H., Hsieh, T.J., Chou Y.C., Chen C.K.H. Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling Delay. Diagnostics. 2022; 12: 2450. https://doi.org/10.3390/diagnostics12102450
2.Barrett T., Brechbiel M., Bernardo M., Choyke P.L. MRI of tumor angiogenesis. J. Magn. Reson. Imaging. 2007; 26: 235–249. https://doi.org/10.1002/jmri.20991
3.Sujlana P., Skrok J., Fayad L.M. Review of dynamic contrast-enhanced MRI: Technical aspects and applications in the musculoskeletal system. J. Magn. Reson. Imaging. 2018; 47: 875–890. https://doi.org/10.1002/jmri.25810
4.Ferrea J.C., Bannierb E. Raoulta H. et al. Arterial spin labeling (ASL) perfusion: Techniques and clinical use. Diagnostic Interventional. Imaging. 2013; 94: 1211–1223.
5.Watts J.M., Whitlow C.T., Maldjian J.A. Clinical applications of arterial spin labeling. NMR Biomed. 2013; 26: 892–900. https://doi.org/10.1002/nbm.2904
6.Madhuranthakam A.J., Yuan Q., Pedrosa I. Quantitative Methods in Abdominal MRI: Perfusion Imaging. Top Magn. Reson. Imaging. 2017; 26 (6): 251–258. https://doi.org/10.1097/RMR.0000000000000145
7.Warmuth C., Gunther M., Zimmer C. Quantification of blood flow in brain tumors: Comparison of arterial spin labeling and dynamic susceptibility-weighted contrastenhanced MR imaging. Radiology. 2003; 228: 523–532. https://doi.org/10.1148/radiol.2282020409
8.Duyn J.H., van Gelderen P., Talagala L., Koretsky A., de Zwart J.A. Technological advances in MRI measurement of brain perfusion. J. Magn. Reson. Imaging. 2005; 22 (6): 751–753. https://doi.org/10.1002/jmri.20450
9.Kawashima M., Katada Y., Shukuya T. et al. MR perfusion imaging using the arterial spin labeling technique for breast cancer. J. Magn. Reson. Imaging. 2012; 35: 436–440. https://doi.org/10.1002/jmri.22882
10.Li X., Metzger G.J. Feasibility of Measuring Prostate Perfusion with Arterial Spin Labeling NMR Biomed. 2013; 26 (1): 51–57. https://doi.org/10.1002/nbm.2818
11.Cai W., Li F., Wang J. et al. A comparison of arterial spin labeling perfusion MRI and DCE-MRI in human prostate cancer. NMR Biomed. 2014; 27 (7): 817–825. https://doi.org/10.1002/nbm.3124
12.Fujima N., Kudo K., Tsukahara A. et al. Measurement of tumor blood flow in head and neck squamous cell carcinoma by pseudo-continuous arterial spin labeling: Comparison with dynamic contrast-enhanced MRI. J. Magn. Reson. Imaging. 2015; 41 (4): 983–991. https://doi.org/10.1002/jmri.24885
13.Winter J.D., St Lawrence K.S., Cheng, H.L. Quantification of renal perfusion: Comparison of arterial spin labeling and dynamic contrast-enhanced MRI. J. Magn. Reson. Imaging. 2011; 34 (3): 608–615. https://doi.org/10.1002/jmri.22660
14.Nery F., Buchanan C.E., Harteveld A.A. et al. Consensus-based technical recommendations for clinical translation of renal ASL MRI. Magnetic Resonance Materials in Phys., Biol. and Med. 2020; 33: 141–161. https://doi.org/10.1007/s10334-019-00800-z
15.Englund E.K., Rodgers Z.B., Langham M.C. et al. Measurement of Skeletal Muscle Perfusion Dynamics With Pseudo-Continuous Arterial Spin Labeling (pCASL): Assessment of Relative Labeling Efficiency at Rest and During Hyperemia, and Comparison to Pulsed Arterial Spin Labeling (PASL). Magn. Reson. Imaging. 2016; 44 (4): 929–939. https://doi.org/10.1002/jmri.25247
16.Baligand C., Hirschler L., Veeger T.T.J. et al. A split-label design for simultaneous measurements of perfusion in distant slices by pulsed arterial spin labeling. Magn. Reson. Med. 2021; 86: 2441–2453.
17.Xu L., Xu L., Zhu H. Evaluation of three-dimensional arterial spin labeling perfusion imaging for the pathological investigation of musculoskeletal tumors. Exp. Ther. Med. 2018; 15 (6); 5029–5034. https://doi.org/10.3892/etm.2018.6030
18.Lin C.H., Hsieh, T.J., Chou Y.C., Chen C.K.H. Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling. Delay. Diagnostics. 2022; 12 (10): 2450. https://doi.org/10.3390/diagnostics12102450
Contrast-free MR-perfusion of ''labeled arterial blood spins'' (''ASL-perfusion'') is an MR-technology for qualitative and quantitative assessment of tissue perfusion properties based on of arterial blood proton spins labeling by radiofrequency pulses and their subsequent measurement when passing through the area of interest. The most of ASL-perfusion application clinical data referred to central nervous system diseases diagnostics, but some works showing the effectiveness of this technique in assessment of skeletal muscle perfusion and diagnostics of soft tissue tumors appeared recently.Two presented clinical cases (soft tissue tumor and post-traumatic benign changes) demonstrate the possibility of this technique usage to assess vascularization of pathological changes in hip soft tissues.
Keywords:
опухоли мягких тканей, мультипараметрическая магнитно-резонансная томография, ASL-перфузия, soft tissue tumors, multiparametric magnetic resonance imaging, ASL-perfusion